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Yale findings hold promise for stopping progression of bipolar disorder

Endowment Policy Changes in the brain that are important indicators of bipolar disorder are not prominent until young adulthood and are reduced in persons taking mood-stabilizing medications, Yale School of Medicine researchers report this month in Biological Psychiatry.

This topic discusses bipolar disorder in adults. If you are concerned that your child or teen may have bipolar disorder, see the topic Bipolar Disorder in Childhood and Adolescence.

Selling Endowment The researchers used magnetic resonance imaging to measure a part of the brain that regulates emotions, the ventral prefrontal cortex, that lies above the eyes. The changes in persons with bipolar disorder were not prominent until young adulthood, suggesting that the illness progresses during the teenage years. Bipolar disorder is also known as manic-depressive illness.

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Endowment Mis Selling "The brain changes were diminished in persons with bipolar disorder who were taking mood-stabilizing medications," said Hilary Blumberg, M.D., associate professor in the Department of Psychiatry and director of Yale's Mood Disorders Research Program. "This brings hope that it may someday be possible to halt the progression of the disorder."

First Person Do you feel really "up, " then really "down" If so, you may have bipolar disorder. Check out one patient's story. Risk Assessment Certain genetic and lifestyle factors may increase your risk of developing bipolar disorder. Find out more now. Planning Ahead When it comes to children's manic episodes, prevention is the best medicine. Find out how to help your child manage his or her disorder.

Selling Endowment Policy Blumberg added, "Research to understand bipolar disorder in youths is especially important because of their high risk for suicide."

Over 3 million Americans—about 1% of the population, or 1 in every 100 people—have bipolar disorder, with similar rates in other countries.¹ Bipolar disorder occurs equally among males and females. It often begins between the ages of 15 and 24.²

Endowment Fund Bipolar disorder is characterized by episodes that range from emotional highs, or manias, to emotional lows, or depressions. Extreme manic highs can be associated with over-spending, impulsiveness on the job or at school, and risky behaviors, including sexual indiscretions that can lead to loss of important relationships. Blumberg said in depressive episodes individuals may "take to bed" or, in severe cases, try to take their own lives.

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